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Development of Bio-nano Hybrid Materials and Diagnostic Systems (BEETLES2)

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  • 2023-03-22
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Professor Jung-hoon Lee's Team Develops High-sensitivity on-site Diagnosis Technology Applicable to Pandemic, Endemic, and New and Variant Infectious Diseases in the Future

- Published in Nature Communications IF: 17.69 -

- Securing Virus Sample Pre-processing Technology Within 3 Minutes Through the Development of Bio-nano Hybrid Materials -

- Development of PCR-level High-sensitivity on-site Diagnostic Technology Through the Use of Rapid Kits Combined With Pretreatment -

- Highly Sensitive Monitoring of COVID-19 Pandemic, Endemic as Well as New and Variant Viruses - 

 

Professor Junghoon Lee's team (Department of Electrical Engineering) successfully developed Bio-nano hybrid materials and diagnostic systems (BEETLES2) through joint research with Korea University’s Prof. Yoon Dae-seong's team, Seoul St. Mary's Hospital’s Prof. Seong-yeon Cho's team, Catholic Kwandong University’s Prof. Yoo Yong-Kyung's team and Calth Co., Ltd.

  

This study was conducted with the support of the National Research Foundation of Korea's Biomedical Technology Development Project (No.2021M3E5E3080743) and was published in Nature Communications IF: 17.69, a world-class top-tier paper published by Nature Portfolio.

 

Web link: https://www.nature.com/articles/s41467-023-37018-6

 

<From left, Prof. Junghoon Lee (Kwangwoon University), Sung-Joon Park (Master's course), Seung-Min Lee (Ph.D. course), Dong-Taek Lee (Post-Doctoral course: Harvard Medical School), Prof. Dae-Sung Yoon (Korea University), Prof. Yoo Yong-Kyung (Catholic Kwandong University)>

<From left, Prof. Junghoon Lee (Kwangwoon University), Sung-Joon Park (Master's course), Seung-Min Lee (Ph.D. course), Dong-Taek Lee (Post-Doctoral course: Harvard Medical School), Prof. Dae-Sung Yoon (Korea University), Prof. Yoo Yong-Kyung (Catholic Kwandong University)>

 

<Picture description> Separation and concentration system using hybrid filter (BEETLES2) and operation principle. By applying this system, immunodiagnosis, molecular diagnosis, and on-site diagnosis are possible, and quick response to new/mutant viruses is possible. By simply using hand pressure, the sensitivity of the PCR level (Ct standard of 35 or more) is secured. The sensitivity and accuracy of low titer/initial patient diagnosis were greatly increased from 14.29% and 41.94% (existing commercialized rapid kit) to 88.1% and 91.9% (BEETLES2 application) through a 3-minute pre-processing process in the field, and new variant infectious diseases is likely to be applied in the future.

<Picture description> Separation and concentration system using hybrid filter (BEETLES2) and operation principle. By applying this system, immunodiagnosis, molecular diagnosis, and on-site diagnosis are possible, and quick response to new/mutant viruses is possible. By simply using hand pressure, the sensitivity of the PCR level (Ct standard of 35 or more) is secured. The sensitivity and accuracy of low titer/initial patient diagnosis were greatly increased from 14.29% and 41.94% (existing commercialized rapid kit) to 88.1% and 91.9% (BEETLES2 application) through a 3-minute pre-processing process in the field, and new variant infectious diseases is likely to be applied in the future.
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