Prof. Park Jae-Young’s Team Develops a Skin Patch Sensor That Simultaneously Measures Blood Sugar...
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- 2021-11-17
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Professor Park Jae-Young’s Team Develops a Skin Patch Sensor That Simultaneously Measures Blood Sugar and ECG
Professor Park Jae-Young's research team (Department of Electronic Engineering) has succeeded in developing a 'multifunctional hybrid skin patch sensor for wearable smart medical and healthcare systems'. The patch sensor developed by his research team is capable of non-invasive blood sugar monitoring and continuous electrocardiogram measurement through accurate sweat sugar detection.
Professor Park Jae-Young (left) and Yoon Sang-hyeok (right)
Recently, as the interest and importance of metabolic syndrome
and chronic disease management due to westernized diet and aging continues to
increase, the need for wearable smart medical and healthcare systems using bio
signal real-time monitoring technology is greatly increasing. Therefore,
research on patch sensor technology that can non-invasively monitor the user's
chemical bio signals (blood sugar, lactate pH, etc.) and physiological signals
(electrocardiogram, electromyography, brainwave, etc.) in real time is being
actively conducted at home and abroad.
In particular, sensor technology for measuring and real-time
monitoring of blood glucose in bodily fluids such as tears, sweat, and
interstitial fluid (ISF) is being studied the most. However, most of the patch
sensor-related studies reported so far are technologies that measure only
chemical bio signals or physiological signals, and there is a limit to the
application of next-generation smart health care and disease diagnosis systems
that require complex and multiple bio signals. Also, since blood sugar obtained
from sweat is affected by temperature and pH, it is essential to correct it.
The research team developed a hybrid path sensor which is a new
concept that can simultaneously measure body temperature, chemical bio signals
(blood sugar, pH), and physiological signals (electrocardiogram,
electromyography) by overcoming the pain caused by frequent blood collection
and the inconvenience of attaching multiple patch sensors to the body. It is a
multi-flexible patch sensor that integrates several electrochemical and
physiological sensors on one flexible substrate so that the temperature and pH
correction sensors are integrated with the sweat sensor to accurately detect
blood glucose from sweat and continuously measure electrocardiograms. After
applying a two-dimensional nanomaterial, reduced graphene oxide (rGO) thin
film, on the micropatterned electrode, the surface characteristics analysis and
material and device process conditions are optimized through physical/chemical
property data (Cyclic voltammetry, FE-SEM, XPS). The performance of the sensor
is greatly improved.
The developed blood glucose sensor showed high linearity
(R2=0.99) and sensitivity (29.10 ?A mM?1cm?2) within the effective range of the
body. It showed similar characteristics. In addition, as a result of conducting
an on?body test based on human sweat, the validity of the hybrid skin patch
sensor manufactured by comparison with commercial skin analysis equipment was
verified. The skin patch sensor developed in this study is greatly used in
research for smart management of chronic diseases and metabolic syndrome
through big data analysis and the establishment of a u? healthcare DB through
various complex biometric information collected based on wearable medical and
healthcare platform technology.
Meanwhile, this research was carried out with the support of the Biomedical Technology Development Project (NRF-2017M3A9F1031270) of the Ministry of Science and ICT. and Bioelectronics, (IF:10.618) https://doi.org/10.1016/j.bios.2021.113685
Hybrid skin patch sensor and measurement results for wearable smart medical and healthcare applications